The antonyms for the word "most aligned" are multiple, and it depends on the context in which the word is used. When referring to ideas, beliefs, or values, antonyms can include divergent, unalike, conflicting, or opposing. In terms of physical alignment, related antonyms can be askew, crooked, skewed, or tilted. When it comes to relationships or political affiliation, antonyms may be dissociated, disconnected, or unconnected. In conclusion, antonyms for the word "most aligned" can vary based on the context, but they typically describe a misalignment, inconsistency, or difference in ideas, values, relationships, or physical positioning.