Most blitzed essentially means the highest degree of being intoxicated or drunk. There are many different synonyms that can be used to describe someone who is in this state. These include terms like hammered, plastered, wasted, sloshed, smashed, and tanked, among others. Depending on the context and the level of formality needed, different synonyms may be appropriate in different situations. However, all of these terms convey the same general sense of being very drunk and possibly unable to function normally. When encountering someone who is most blitzed, it's important to treat them with care and compassion, and to ensure their safety until they have sobered up.