The antonyms for the phrase "most case-hardened" are words that express softness and gentleness, such as tender, lenient, flexible, affectionate, sympathetic, and considerate. These words describe individuals who are empathetic and understanding towards others, and who are not harsh or judgmental. These antonyms can be used to express the opposite of a person who has been case-hardened by life experiences, and who may lack empathy or compassion. It is important to remember that although some people may have a tough exterior, it is possible for them to have a soft and caring heart beneath the surface, which should be acknowledged and appreciated.