Most cross-grained is an expression that denotes stubbornness and obstinacy. The antonyms for this phrase, however, would be agreeable, amiable, flexible, and pliable. These terms indicate a willingness to be accommodating and adaptable in one's outlook and behavior. Additionally, other antonyms for cross-grained include affable, benevolent, cordial, gracious, genial, and congenial. These words convey the notion of being friendly and pleasant, rather than difficult or challenging. Whether in personal or professional relationships, it is always beneficial to strive for qualities that promote understanding and cooperation, rather than resistance and opposition.