When looking for synonyms for the word "most desperately," one can use expressions such as "urgently," "desperately," "crucially," or "imperatively." Other options could include "direly," "pressingly," "gravely," or "acutely." These words convey a sense of urgency and desperation, indicating that something needs to be done immediately or else there will be dire consequences. It is important to choose the right synonyms depending on the context and the level of urgency that needs to be conveyed. Sometimes, adding a descriptive word can strengthen the effect of the message, such as "frantically," "wildly," or "urgently".