Most disabused refers to the state of being well-informed and knowledgeable after dispelling any illusions or misconceptions. The antonym for this term would be the state of being naive, gullible or ignorant. Thus, the opposite of most disabused would be most beguiled, most credulous, most deluded, most duped, most misled or most deceived. These words describe an individual who is easily fooled, lacks awareness, or has a limited understanding of the truth. Therefore, while most disabused implies a degree of insight and wisdom, its antonyms suggest a lack of critical thinking, skepticism, and awareness of reality.