Antonyms for "most doubtless" include "uncertain," "doubtful," "questionable," "hesitant," "dubious," and "suspect." These words all suggest a lack of confidence or certainty in something. When someone uses the phrase "most doubtless," they are essentially stating that something is very likely to occur or be true. The opposite is true when using any of the aforementioned antonyms. For example, if someone says something is uncertain or questionable, they are implying that it may not happen or may not be true. Using antonyms can help provide a balanced view of a situation and prevent overly optimistic or unrealistic expectations.