Antonyms for the word "most endeared" can include "detested," "hated," "despised," "abhorred," and "reviled." These words all convey a sense of deep dislike or aversion towards something or someone. While "most endeared" suggests a sense of warmth, affection, and care, its antonyms paint a very different picture. When something is detested or hated, it is actively avoided or rejected. On the other hand, when we hold something most endeared, we cherish it and hold it close to us. The antonyms for this word remind us of the power of negative emotions and feelings, and the importance of finding things to hold dear in our lives.