The antonyms for the word "most entwined" are "separate," "detached," "unrelated," "unconnected," and "isolated." These antonyms signify a sense of distance and disconnection between two or more entities, as opposed to the close association and intertwined nature implied by the word "entwined." When things are separated or detached, they exist independently of one another and do not interact or influence each other. This makes the antonyms of the word "most entwined" particularly useful in situations where it is necessary to emphasize differences, distinctions, or boundaries between different concepts, people, or things.