The word "most freaked-out" has many antonyms depending on the context. If it refers to someone who is calm and composed, antonyms may include serene, tranquil, peaceful, or placid. For someone who is excited or enthusiastic, opposite words may be bored, disinterested, blase, or apathetic. When referring to someone who is not afraid, antonyms may include fearless, brave, courageous, or confident. If it describes someone who is not confused or disorientated, antonyms could be clear-headed, focused, sensical, or rational. Ultimately, the antonyms for "most freaked-out" will depend on the context and the desired meaning.