The antonyms for the word "most front-page" could vary depending on the context used. If it's in the sense of popularity, the antonyms could be "least popular," "unnoticed," or "unremarkable." If it's referring to the position or location, antonyms could be "at the back," "hidden," or "low profile." In terms of significance, the antonyms for "most front-page" could be "insignificant," "irrelevant," or "trivial." It's important to consider the context when thinking about antonyms for any word, as it would affect the opposite meaning intended.