The word "gainless" refers to something that does not result in any gain or benefit. Therefore, antonyms for the phrase "most gainless" would be words such as "most beneficial," "most advantageous," "most profitable," or "most fruitful." These words suggest things that are valuable or useful, resulting in a positive outcome. For instance, gaining education through reading, taking on a new project, or networking with others can be beneficial in many ways. Conversely, wasting time, procrastinating, or engaging in negative behavior can be considered "most gainless." In short, it is essential to seek out activities that offer the most gain and avoid anything that may lead to negative outcomes.