Most goofed means making the biggest mistake or error. Antonyms for this could be words that express excellence or skill. Words like flawless, exemplary, faultless, or impeccable. Another set of antonyms that could be used for most goofed may be words that indicate accuracy, precision or correctness, such as accurate, precise, exact, or correct. Other opposites for most goofed could be words that imply being aware and attentive, like attentive, vigilant, or cautious. Overall, the antonyms for most goofed are words that express proficiency, perfection or vigilance.