The phrase "most hair-splitting" refers to something that is excessively nitpicky or overly concerned with small details. There are several synonyms for this term, including "pedantic," "quibbling," "hypercritical," and "fastidious." All of these words capture the essence of a person or situation that is obsessively focused on minor details to the point of being frustrating or irritating. Other related terms might include "meticulous," "fussy," or "punctilious." Whether describing a person's attention to detail or a particular situation that requires extreme precision, these words all convey a sense of something that is painstakingly precise or nitpicky to the point of being excessive.