The antonyms for the word "most handpicked" will depend on the context in which it is used. If the word refers to something being carefully selected or chosen, then the antonyms could be "unselected", "unaltered", "unsorted", "unpicked", "unscanned", "unfiltered", "unexamined", "uninspected", or "untested". If "most handpicked" is used in a positive sense, then its antonyms would be terms that indicate the opposite, such as "least preferred", "least desirable", "worst", "least qualified", "least talented", "least competent". Therefore, antonyms of a word change based on the context it is used in.