The antonyms for the word "most healthy-looking" can vary depending on the context in which the term is used. For example, the antonyms could be "unwell", "sickly", or "pale" if describing a person's appearance. If referring to food, the antonyms could be "unappetizing", "unhealthy", or "unappealing". Similarly, in the world of cosmetics and skincare, the antonyms could be "blemished", "blemished", or "pimpled". The antonyms for "most healthy-looking" basically represent the opposite of a desirable, healthy exterior. It is important to choose the appropriate antonyms based on the context and content of the sentence or phrase.