When it comes to describing someone who is most heart-stricken, there are several synonyms that can be used. Some of the most common ones include devastated, shattered, brokenhearted, grief-stricken, despairing, and anguished. Each of these words conveys a sense of extreme emotional pain and sorrow, and can be used interchangeably with most heart-stricken in most situations. Depending on the context, other synonyms may also be appropriate, such as bereaved, suffering, tormented, or inconsolable. Ultimately, the choice of synonym depends on the specific nuances of the emotional state being described, and the writer's desired tone and emphasis.