The term "most high and mighty" is indicative of a supreme status or authority that one may possess. However, antonyms for this phrase would include words like lowly, humble, insignificant, or powerless. These terms represent the opposite of dominance and superiority that the phrase "most high and mighty" conveys. While the former can refer to a position of immense influence and importance, the latter suggests meekness and lack of influence. These antonyms can be used to describe those who are not powerful, wealthy, or influential. Therefore, the context in which these antonyms are used can determine their impact and meaning.