The phrase "most high-brow" suggests something that is sophisticated, intellectual, and often associated with art and culture. Its antonyms, on the other hand, point to something that is not refined, simplistic, and lacking in cultural depth. Some potential antonyms for "most high-brow" could include "low-brow," "crass," "vulgar," "unsophisticated," "common," or "popular." These words can all convey a sense of anti-intellectualism, catering to a more mass audience, and perhaps lacking the depth and complexity of high culture. While there is no inherent value judgment in these antonyms, they do emphasize a tension between popular culture and more esoteric forms of art and knowledge.