The antonyms for the word "most homelike" would be words that describe the opposite of feeling at home or comfortable in a place. These antonyms could be words such as unfamiliar, uncomfortable, impersonal, sterile, or cold. When a place is not homelike, it may feel inhospitable, unwelcoming, or unfriendly. A person may feel disconnected or out of place in a non-homelike environment. Therefore, it is important to create a homelike atmosphere in places like hospitals, schools, and public spaces so that people feel comfortable and welcome. The opposite of a homelike environment may create negative feelings, which is why it is essential to consider the design and ambiance of a space.