The antonyms for the word "most hypersensitive" are "least sensitive," "insensitive," and "thick-skinned." These words convey a lack of sensitivity or a reduced ability to feel emotions strongly. While hypersensitivity can be a valuable trait in some instances, particularly in the realm of empathy and emotional intelligence, it can also be overwhelming or distressing for those who experience it. By contrast, being less sensitive or insensitive can be helpful in certain situations, such as when dealing with difficult or traumatic events. Ultimately, the ideal level of sensitivity will depend on the individual and the circumstances in question.