Most ill-at-ease is a phrase used to describe extreme discomfort or uneasiness in a situation. Antonyms for this phrase include calm, comfortable, composed, confident, content, easy, relaxed, and serene. Feeling calm and composed is the polar opposite of feeling ill-at-ease. When someone is comfortable or easy-going, they are not struggling to adjust to a situation or environment. Confidence plays a big role in feeling at ease, as it provides a sense of security and control. Feeling content and serene are other antonyms, which indicate a state of peacefulness and tranquility. Overall, these antonyms describe a sense of ease and comfort that is the opposite of feeling most ill-at-ease.