The word "most intertwined" refers to two or more things that are deeply connected and closely linked to each other. The antonyms for this term include "separate," "discrete," "detached," "isolated," and "distinct." These words signify a lack of connection, separation, or independence between two or more entities. For example, if two paths are separate, they do not intersect, and if two ideas are distinct, they are not related to each other. Similarly, if two objects are detached, they are not connected physically or emotionally. Therefore, the opposite of "most intertwined" is any word that indicates a lack of connection or separation between things.