The opposite of "most itching" is "least itching." While "most itching" indicates an intense feeling of discomfort or irritation on the skin, "least itching" implies a minimal or negligible sensation.
Other antonyms for "most itching" may include "soothing," "calming," "cool," "comfortable," "pleasing," "delightful," and "relaxing." Sometimes, using a strong antonym like "soothing" or "calming" may not be appropriate because it may not address the level of discomfort the person is feeling.
Therefore, it is essential to choose the right antonym based on the person's current state and the level of itching they are experiencing. In most cases, however, the opposite of "most itching" is simply "least itching.