Antonyms for the phrase "most knownothing" could include "well-informed," "knowledgeable," "expert," "familiar," "adept," "experienced," "learned," "proficient," "in the know," and "versed." These words describe individuals who possess a high level of understanding in a particular area, whether it's a skill, subject matter or industry. They are fully aware of the facts, data, and information related to their domain, and can provide valuable insights and advice to others. In contrast, "most knownothing" implies a complete lack of knowledge or awareness, which can limit an individual's ability to make informed decisions and succeed in their pursuits.