"Most low-life" refers to someone who is considered to be immoral or despicable. Antonyms for this phrase can include adjectives such as upstanding, respectable, honorable, and virtuous, all of which describe someone who is considered to be of high moral character. Other antonyms might include terms such as reputable, esteemed, dignified, or admirable, all of which convey a sense of respect or admiration for a person. Overall, antonyms for "most low-life" are words that convey positive traits or characteristics, and describe someone who is considered to be a good, decent, and upright member of society.