When we talk about something being "most machine-driven," we're describing it as being largely automated or computerized in its operation. Some antonyms, or words with opposite meanings, for this phrase might include "hand-operated," "manual," or "mechanical." These terms all suggest a more hands-on approach to a task or process, where human intervention or physical labor is necessary to achieve a desired outcome. Other possible antonyms might include "organic," "natural," or "analog," all of which imply a less mechanized, more intuitive or traditional approach to a given undertaking. Ultimately, the choice of antonym will depend on the context and specific application of the term "most machine-driven.