The antonyms for the word "most malefic" can include terms like beneficial, auspicious, advantageous, benign, favorable, helpful, wholesome, salutary, propitious, and lucky. These words refer to things that are positive, fortunate, or beneficial. While "most malefic" implies something that is harmful or evil, these antonyms suggest the opposite - that which brings about positive outcomes and effects. Using these antonyms can help one easily convey a positive and hopeful meaning in sentences, rather than emphasizing the negative or malicious intentions.