Most mollifying refers to something that is calming, soothing, or pacifying, but the opposite of this would be a word that suggests agitation, irritation, or provocation. Therefore, the antonyms for most mollifying could include terms such as annoying, aggravating, infuriating, vexing, or agitating. These words suggest an irksome, irritating or frustrating experience. Instead of calming and soothing, they can cause annoyance and irritation. Therefore, it is important to consider the context in which these words are used before picking out the suitable antonym. Overall, antonyms of most mollifying indicate a contrary emotion or feeling that can stimulate or irritate someone.