Most near at hand means something that is closest or most easily accessible. Opposite to this, the antonyms could refer to something distant or far away. For instance, distant, remote, far-off, or faraway could be antonyms for most near at hand. Similarly, inaccessible, inconvenient, remote, or out of reach could also be antonyms for most near at hand, as they describe something that is not easily available or approachable. Further antonyms could include obscure, hidden, or unknown as they describe something that is not easily visible or recognizable. Therefore, the antonyms for most near at hand refer to something distant or hidden that is difficult to reach or access.