The antonyms for the word "most nocent" can be significant, harmless, innocent, beneficent, advantageous, benign, good, etc. Most nocent refers to something that is highly harmful or injurious, and its antonyms refer to something that is beneficial or positive in nature. For instance, harmless refers to something that does not cause harm or damage, whereas beneficent emphasizes the virtue of doing good, especially for others. Similarly, benign and innocent also refer to something that is gentle, harmless, and free from any negative consequences. Thus, the antonyms for most nocent help us to understand the opposite nature of the word and provide us with different shades of meaning to express ourselves more accurately.