The antonyms of the phrase "most out of sorts" can be words like content, satisfied, peaceful, calm, and serene. While feeling out of sorts can mean feeling irritated, discombobulated, or unsettled, the opposite emotions are experienced when one feels content and satisfied. A peaceful and calm mind is one that is balanced and not disturbed by external factors. Serenity means a state of being tranquil and undisturbed. When someone is out of sorts, their mood is characterized by frustration and discomfort, but when they feel content and peaceful, their mood is uplifted and harmonious. By using antonyms, one can describe a range of emotions that are opposite to feeling out of sorts.