Antonyms for the phrase "most out-of-it" indicate the opposite of being in a state of confusion or disorientation. Some possible antonyms include "alert," "awake," "aware," "conscious," "focused," "sober," and "oriented." Being alert means being attentive and vigilant, while being awake implies being fully conscious after sleep. Being aware suggests understanding one's surroundings, and being conscious means being present in the moment. Being focused refers to having one's attention directed toward a particular goal or objective, while being sober indicates being free from the influence of drugs or alcohol. Finally, being oriented means having a clear understanding of one's position and the direction to take.