The term "most profitless" refers to something that has little or no value in terms of financial gain or personal benefit. Some antonyms for this word might include "lucrative," "rewarding," "advantageous," "gainful," "beneficial," "fruitful," "profitable," "productive," "remunerative," and "valuable." These terms all describe something that is worth pursuing or investing in because it can lead to financial or personal gain. By contrast, "most profitless" implies that the effort or resources invested are unlikely to bring any return, making it a waste of time and effort. Antonyms for this word help to point out the potential for gain and the benefits of pursuing a certain course of action.