Antonyms for the word "most regarded" would include terms like "least relevant," "least important," "least esteemed," and "least respected." These words all indicate a low rank or value assigned to something, indicating that it is not valued highly in the eyes of others. Other possible antonyms might include phrases like "least valued," "ignored," or "dismissed." People or things that are the antithesis of the most regarded may be perceived as less competent, less accomplished, or less worthy of attention or admiration. It is important to note that what is considered "most regarded" may vary greatly depending on context, culture, and individual perspectives.