Most sainted refers to someone who is highly regarded as being morally pure or virtuous. Antonyms for the word most sainted would be those who are perceived as being immoral or unrighteous. Some antonyms could include "sinful," "wicked," "evil," "unholy," "corrupt," "depraved," or "vicious." These words express a lack of moral character or virtue, in contrast to someone considered the most sainted. While most sainted may be used to describe a religious figure, such as a saint, the antonyms describe someone who is not held in such high esteem and may be viewed negatively by society.