Most senselessly means doing something without reason, logic or understanding. Antonyms for the word include intelligently, reasonably, logically, sensibly and purposefully. When someone does something with purpose and reason, it is usually the opposite of being senseless. You can also say that the opposite of most senselessly is thoughtful and considerate. Making a thoughtful decision is the opposite of making a senseless one. Sensible choices are logical and practical, while most senseless choices lack logic and reason. Overall, the antonyms for most senselessly emphasize the importance of making choices with logic, reasoning, and purpose.