The antonyms of "most sharp-sighted" can vary depending on the context. In terms of vision, antonyms may include "nearsighted," "farsighted," or even "blurred." In other contexts, antonyms may include "unobservant," "careless," or "negligent." Antonyms can also vary depending on the degree of sharpness being compared, with options such as "less sharp-sighted," "average," or "dull." The choice of antonym depends on the specific comparison being made and the intended meaning behind it. While "most sharp-sighted" implies exceptional visual perception or awareness, antonyms can offer alternative perspectives or degrees of comparison.