Most simplehearted is a term used to describe someone who is pure at heart and exhibits honesty, kindness, and empathy. Antonyms for most simplehearted would be someone who is deceitful, manipulative, and insincere. They lack compassion, sympathy, and genuine care for others. They may also be described as selfish, arrogant, and insensitive. These individuals prioritize their interests above others and are often seen as cold-hearted and callous. Words such as calculating, uncaring, and ruthless would also be used to describe individuals who are antonyms for most simplehearted. Overall, the antonyms for most simplehearted highlight the stark contrast between someone who is genuinely kind and someone who is indifferent towards others.