The phrase "most smart-mouthed" is often used to describe someone who is quick-witted with often sarcastic or cutting remarks. However, there are several other synonyms that can be used to describe such a person. Some of these words include sassy, snarky, facetious, impudent, irreverent, flippant, acerbic, and tongue-in-cheek. Each of these words emphasizes a slightly different aspect of being smart-mouthed, but they all imply a certain level of disrespect or irreverence towards authority or convention. Whether being used as an insult or a compliment, these synonyms show the power of language in describing human behavior and personality.