The antonyms for the word "most soothed" would be "least comforted," "agitated," or "distressed." In contrast to feeling soothed, these antonyms describe a state of unease or discomfort. For example, when we experience an unpleasant situation, we may feel agitated or distressed instead of soothed. The opposite of being comforted is feeling uneasy or anxious. When we encounter painful emotions, our state of mind can be disturbed. Therefore, the antonyms of "most soothed" can help us understand the range of human emotional experiences and how they can be expressed linguistically.