The antonyms for "most spread-out" can vary depending on the context of the phrase. However, some possible antonyms could be "compact," "dense," "concentrated," "clustered," or "crowded." These terms suggest a concentration of people, objects, or elements within a confined area, as opposed to something that is widely dispersed. For example, a crowded street may have a high concentration of people in a small area, while a spread-out suburban neighborhood may have houses and properties dispersed over a wide area. In general, the antonyms for "most spread-out" suggest a sense of closeness or proximity, rather than a sense of distance and separation.