When describing someone as "most telegenic," there are many synonyms that can be used to convey a similar meaning. One possible substitute could be "camera-friendly," which suggests that the person in question looks good on screen and knows how to present themselves effectively. Another option might be "photogenic," which conveys a similar sense of being visually attractive in a way that translates well to televisual media. Other possibilities might include "media-savvy," "charismatic," or "appealing," all of which suggest an ability to command attention and interest on camera. Ultimately, the most appropriate synonym will depend on the context and tone of the conversation.