Most trammeled refers to something that is restricted or hindered, but its antonyms would relate to freedom and ease. Some possible antonyms for the word "most trammeled" include "unhindered," "unfettered," "unrestricted," "unencumbered," "free," "unrestrained," "loose," "liberated," "unbound," "uncaged," "unimpeded," and "unbridled." Each of these words suggests a sense of liberation, whether from constraints or boundaries, and a sense of movement and flexibility. Using these antonyms can help convey the opposite meaning of what is typically implied by most trammeled, providing a richer and more nuanced description of any given situation or scenario.