The word "most two-fisted" is an idiom used to describe someone or something that is tough, strong, and powerful. The antonyms for this phrase would be weak, feeble, and powerless. These words are used to describe someone or something that lacks strength, stamina or resilience. While "most two-fisted" is often used to describe a person's physical abilities, the antonyms are used to depict someone who is fragile, vulnerable, and helpless. In conclusion, the antonyms of "most two-fisted" represent the opposite of what this phrase stands for, emphasizing the lack of strength, ability or capacity to take action.