The antonyms for the word "most unsanctified" could include words such as pure, virtuous, holy, sacred, righteous, and blessed. These words are the complete opposite of unsanctified, which refers to something that is not holy, unpurified, or impure. When facing a situation where one needs to describe something that is the opposite of unsanctified, they can use these words to convey the opposite meaning. For instance, to describe a person as virtuous is to imply that they are morally upright, honorable, and ethical. Similarly, describing a place as sacred indicates that it is respected, revered, and hallowed.