The antonyms for the word "most unvexed" include "disturbed," "agitated," "troubled," "discontented," and "worried." These words imply a state of mind or situation that is characterized by stress, anxiety, or discomfort. In contrast, the opposite of "most unvexed" would be a state of peace, calm, and serenity. Antonyms for "most unvexed" could include words like "tranquil," "serene," "calm," "relaxed," or "unperturbed." These adjectives describe a situation or state of mind that is free from any sort of disturbance or anxiety, and which provides a sense of comfort and contentment.