The antonyms for the word "most vexed" are "calm," "content," and "pleased." These words are used to describe a state of tranquility, satisfaction, and joy. When we are "calm," we are peaceful and free from agitation or excitement. When we are "content," we are satisfied with what we have and not desiring anything more. When we are "pleased," we are happy and joyful about a particular situation or thing. Therefore, using antonyms for "most vexed" could help to express positivity and alleviate negative feelings associated with being vexed or irritated.