The antonyms for the word "most weighed" include "least weighed," "lightest," "smallest," "negligible," and "insignificant." These words denote a sense of lack or absence of weight, importance, or significance. While "most weighed" implies a sense of heaviness, seriousness, or significance of something, its antonyms carry the opposite meaning. For instance, if you say that the most weighed factor in a decision is cost, its antonym would be that the least weighed factor is cost. Similarly, if you say that a problem is of the most weighed importance, its antonym would be that the problem is negligible or insignificant.