Antonyms for the phrase "most well disposed" would include words such as unfriendly, hostile, antagonistic, unfavourable, and negative. While "well disposed" suggests a positive or favourable attitude, its antonyms convey the opposite: a lack of enthusiasm or willingness to help. Such negative sentiments can be harmful to interpersonal relationships and can result in conflict and misunderstandings. It is important to acknowledge and address any hostile or unfriendly behaviours towards others, and strive to maintain a positive and open-minded attitude towards all. By doing so, we can cultivate better relationships and create a more harmonious and productive society.